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- W2381177976 abstract "Objective To investigate the anti-recurrence effect of Yu Ping Feng Powder on herpes simplex keratitis(HSK)and the mechanism of that by observing its influence on cellular immune function of HSK model mice at different infection stage.Methods The expression level of CD3+,CD4+,CD8+(T-lymphocytes)at different infection phases were detected by flow cytometry.The content of γ-IFN,IL-2,IL-4 and IL-10(cytokines)in serum at different infection phases were also tested by ELISA.Results of those two tests were analyzed.Results The CD3+ and CD4+ expression level at HSK latency stage(PI 28 days)and recurrence stage(UV-B 3 days)were significantly lower,while CD8+ expression level were significantly higher,comparing with those in the normal control group.The γ-IFN,IL-2(Th1-type)content in peripheral blood(PB)at HSK latency stage(PI 28 days)and recurrence stage(UVB 3 days)were significantly lower,while IL-4 and IL-10(Th2-type)content were significantly higher,comparing with those in the normal control group.At the final phase of the treatment,the CD3+,CD4+,CD8+ expression level and PBγ-IFN,IL-2,IL-4 and IL-10 content were greatly improved,comparing with the beginning phase of the treatment,both in the Yu Ping Feng Powder treatment group and the Yu Ping Feng Powder-acyclovir treatment group at the same infection stage.The CD3+,CD4+,CD8+ expression level and PBγ-IFN,IL-2,IL-4 and IL-10 content in the Yu Ping Feng Powder treatment group and the Yu Ping Feng Powder-acyclovir treatment group were obviously improved than those in the acyclovir-only treatment group and the blank control group.Conclusion Yu Ping Feng Powder can enhance the CD3+ and CD4+ expression,weaken the CD8+ expression and improve the value of CD4+/CD8+,which can strengthen cellular immune function." @default.
- W2381177976 created "2016-06-24" @default.
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- W2381177976 date "2013-01-01" @default.
- W2381177976 modified "2023-09-28" @default.
- W2381177976 title "Effects of Yu Ping Feng Powder on cellular immune function of herpes simplex keratitis model mice" @default.
- W2381177976 hasPublicationYear "2013" @default.
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