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- W2381179038 abstract "Background:Evidence-based medicine suggested that probiotic treatment was more effective than placebo in maintaining remission in ulcerative colitis(UC),but did not provide additional benefit in inducing remission.However, two clinical trials published in 2009 showed that VSL#3,a probiotic mixture,was effective for the induction of remission in UC.AimS:To systematically evaluate the effectiveness and safety of probiotics,especially VSL#3 for induction of remission in UC.Methods:MEDLINE,EMBASE,Cochrane Library,CBM and Wanfang Data were searched for randomized controlled trials comparing the induction of remission in UC between probiotics treatment and non-probiotics treatment (placebo or positive control) without language limitation.Information was retrieved by two reviewers independently. RevMan 5.2.10 software was used to perform meta-analysis;subcategory analysis and sensitivity analysis were also performed.Results;Nine randomized controlled trials with a total of 557 UC patients met the inclusion criteria,of which 4 were VSL#3 treatment.From meta-analysis,the odds ratio of probiotics treatment for induction of remission was 2.05 (95%CI;1.14-3.70,P =0.02) when compared with non-probiotics treatment.Subcategory analysis showed that the odds ratio of VSL#3 treatment was 2.35(95%CI:1.45-3.80,P = 0.0005 ),while nonsignificant odds ratios were seen for other probiotics.The adverse effect rate was not significantly different between probiotics/VSL#3 treatment and nonprobiotics treatment.Sensitivity analysis showed that the result of pooled analysis of the nine trials was stable. Conclusions;VSL#3 is safe and superior to non-probiotics treatment for induction of remission in UC." @default.
- W2381179038 created "2016-06-24" @default.
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- W2381179038 date "2012-01-01" @default.
- W2381179038 modified "2023-09-26" @default.
- W2381179038 title "Probiotic Preparation VSL#3 for Induction of Remission in Ulcerative Colitis:A Systematic Review" @default.
- W2381179038 hasPublicationYear "2012" @default.
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