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- W2381181976 abstract "Objective:To explore the effect of Fentanyl citrate on proliferation and invasion of breast cancer cell line MCF-7 in vitro.Methods:MCF-7 cells were treated with Fentanyl citrate of different concentrations(0.000 1 μmol/L,0.01 μmol/L,and 1 μmol/L),MTT assay was used to detect the proliferation of MCF-7 cells;flow cytometry was used to detect the cycle of MCF-7 cells;wound healing assay and invasive cabinet method were used to detect the invasive ability of MCF-7 cells.Results:The results of MTT colorimetry showed that the proliferation rates of MCF-7 cells treated with different concentrations of Fentanyl citrate were(58.84±11.31)%,(54.37±9.89)%,and(51.83±10.33)%,respectively,which were significantly lower than those in control group;in different groups,the proportions of MCF-7 cells in G2/M stage increased,while the proportions of MCF-7 cells in S stage decreased;the results of wound healing assay showed that the healing rates at 48 hours in different experimental groups and control group were(70.41±6.86)%,(64.36±3.87)%,(62.52±4.95)%,and(83.34±4.59)%,respectively;the results of invasive cabinet method showed that Fentanyl citrate played an inhibiting role in invasion and metastasis of MCF-7 cells in vitro.Conclusion:Fentanyl can inhibit the proliferation of human breast cancer MCF-7 cells,arrest the cell cycle at G2/M stage,reduce the invasive ability of MCF-7 cells,and it has big impact on biological characteristics of MCF-7 cells." @default.
- W2381181976 created "2016-06-24" @default.
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- W2381181976 date "2012-01-01" @default.
- W2381181976 modified "2023-09-25" @default.
- W2381181976 title "Effect of Fentanyl citrate on proliferation and invasion of breast cancer cells in vitro" @default.
- W2381181976 hasPublicationYear "2012" @default.
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