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- W2381232224 abstract "Objective To investigate the role of interleukin-9(IL-9) and interleukin-5(IL-5) in the pathogenesis of airway inflammation in asthma.Methods Induced sputum was obtained from 40 asthmatics.20 healthy individuals were enrolled as controls.IL-9,IL-5 and IL-8 in sputum supernatants were assayed by sandwich enzyme-linked immunosorbent assay(ELISA).Results The counts of EOS,the levels of IL-9,IL-5 in induced sputum of the asthmatics were significantly higher than those in the controls(P0.01).Furthermore,these parameters were higher in the asthmatics of acute exacerbation than those of stable phase(P0.01).In the acute exacerbated asthmatics,a positive correlation was found between the level of IL-9 and the percentage of eosinophile(r=0.39,P=0.025),the level of IL-5 and IL-9(r=0.542,P= 0.001),the level of IL-8 and the percentage of neutrophil(r=0.881,P0.001),and the level of IL-9 and IL-8(r=0.528,P=0.002).Conclusion IL-9 is increased in the induced sputum from asthmatics, especially in exacerbation with asthma,suggesting that IL-9 and IL-5 may participate in the modulation of asthmatic airway inflammation." @default.
- W2381232224 created "2016-06-24" @default.
- W2381232224 creator A5054789376 @default.
- W2381232224 date "2009-01-01" @default.
- W2381232224 modified "2023-09-26" @default.
- W2381232224 title "Expression and Significance of IL-9 and IL-5 in Asthma" @default.
- W2381232224 hasPublicationYear "2009" @default.
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