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- W2381235076 abstract "Objective To observe the effect of oxymatrine on the expression of p-JNK in hippocampus and the spatial learning and memory of penicillin-induced epileptic rats,as well as to investigate its mechanisms.Methods 24 SD rats were randomly divided into four groups,which were normal saline control group(NS),epilepsy group(EP),Oxymatraine group(OXY)and JNK inhibitor group(SP600125,SP).Penicillin was intraperitoneally injected in rats to establish epileptic animal model.Behavioral changes were observed and immunohistochemical method was used to measure the number of positive-cell of p-JNK in hippocampus.The spatial learning and memory was tested by Morris Water Maze(MWM).Results Compared with in EP group,the escape latency,swimming distance,times of crossing platform in OXY group were significantly descreased(P0.05);the expression of p-JNK was less in OXY group than that in EP group(P0.05).Conclusion The protection of OXY for the spatial learning and memory in epileptic rats is performed by affecting the activation of JNK signaling pathway." @default.
- W2381235076 created "2016-06-24" @default.
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- W2381235076 date "2011-01-01" @default.
- W2381235076 modified "2023-09-23" @default.
- W2381235076 title "Effect of Oxymatrine on Learning and Memory of Epileptic Rats and the Expression of p-JNK in Hippocampus" @default.
- W2381235076 hasPublicationYear "2011" @default.
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