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- W2381251594 abstract "OBJECTIVE To evaluate the efficacy and safety of single intra-articular injection of etanereept and methotrexate in patients suffering from knee arthritis with rheumatoid arthritis(RA)and spondyloarthropathy(SpA).METHODS The study was a randomized,parallel,controlled clinical trial.The subjects were the RA or SpA patients with the knee arthritis without deformity,moderate or severe bone erosion and obvious joint space narrowing in radiography in the target knees,who had taken at least 6-week therapy with routine dosage of disease modifying anti-rheumatic drugs(DMARDs) before the study.The subjects were randomized in 1∶1 ratio to receive single intra-articular 25 mg etanercept injecfion or 2 mL compound methotrexate 10 mg to the target knee joint after their synovial fluid being drawn away at baseline.They were followed up four weeks after injection.The primary end point was the 4 week change in the modified Hospital for Special Surgery(HSS) knee score for the target knee.RESULTS Forty-seven subjects in the experimental group and twenty three subjects in the control group were included in the trial.The modified HSS knee score for the experimental group was baseline mean 65.64-14.0,follow-up 84.3±0.1(P0.01),the control group baseline mean 68.24-11.4,follow-up 79.4±15.5(P=0.001).A mean(34.94%-38.90%) improvement on the modified HSS knee score was achieved in the experimental group.While(17.9±24.5)% improvement on the moditied HSS knee score was achieved in the control group(P=0.046 7).Adverse events were observed(19.0%) in the experimental group and(44.4%) in the control group.No serious adverse event had been observed.CONCLUSION Single intra-articular 25 rag etanercept injection had a better efficacy than methotrexate.It was an effective and safe therapeutic option for sDA and RA patients who had knee arthritis without obvious change in radiography." @default.
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- W2381251594 date "2013-01-01" @default.
- W2381251594 modified "2023-09-28" @default.
- W2381251594 title "A randomized,controlled clinical study on single intra-articular injection of etanercept and methotrexate in treatment of inflammatory knee arthritis" @default.
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