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- W2381264672 abstract "Objective: To explore the expression and significance of ARHI gene in breast cancer tissue. Methods: Eighty breast cancer tissue samples,forty breast tissue samples adjacent to breast cancer,and twenty normal breast tissue samples were collected,immunohistochemical method and RT-PCR were used to detect the expression levels of ARHI gene in breast cancer tissue,breast tissue adjacent to breast cancer,and normal breast tissue. Results: The expression levels of ARHI protein and ARHI mRNA in breast cancer tissue were statistically significantly lower than those in normal breast tissue and breast tissue adjacent to breast cancer( P 0. 01),which decreased with the increase of histopathological grades( P 0. 05); the expression levels of ARHI protein and ARHI mRNA in breast cancer tissue with lymph node metastasis were statistically significantly lower than those in breast cancer tissue without lymph node metastasis( P 0. 05),but there was no statistically significant difference among breast cancer tissue of different histological types( P 0. 05). Conclusion: The down-regulation of ARHI gene expression shows that ARHI plays an important role in occurrence and development of breast cancer,which provides a basis for diagnosis and prognosis of breast cancer." @default.
- W2381264672 created "2016-06-24" @default.
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- W2381264672 date "2013-01-01" @default.
- W2381264672 modified "2023-09-23" @default.
- W2381264672 title "Expression of ARHI gene in breast cancer tissue and its significance" @default.
- W2381264672 hasPublicationYear "2013" @default.
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