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- W2381266925 abstract "Objective To study the upregulation of expression of Mrp2 and promotion of biliru- bin transport by rhGH in liver tissues of rats with restoration of bile flow(RBF).Methods After common bile duct ligation(CBDL),Wistar rats of 14 days in age were subjected to RBF for test and sham operation.The samples were collected on day 3,7,14 after RBF.Mrp2 of liver tissue was de- termined by irnmunofluorescent microscopy and RT-PCR,serum GH by radioimmunoassay.Mean- while,they correlatively analyzed with GH and bilirubin in the serum.Results After RBF,the ex- pression of Mrp2 increased but the recovery was very slow.The level of Mrp2 in the liver tissue was upregulated by rhGH and was significantly correlated to that of GH in the serum.Conclusions The reason for slow recovery of Mrp2 expression might be down-regulation of serum GH in rats with obstructive jaundice The promotion of bilirubin transport by rhGH can upregulate the expression of Mrp2." @default.
- W2381266925 created "2016-06-24" @default.
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- W2381266925 date "2006-01-01" @default.
- W2381266925 modified "2023-09-24" @default.
- W2381266925 title "Upregulation of expression of Mrp2 and promotion of bilirubin transport by rhGH" @default.
- W2381266925 hasPublicationYear "2006" @default.
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