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- W2381270878 abstract "Objective To study the effects of L-arginine(L-Arg) on pulmonary thromboembolism(PTE) and its possible mechanism. Methods Seventy-two rats were randomly divided equally into control group,model group,and treatment group.PTE model was established by intravenous injection of auto-blood clots.In treatment group,L-Arg 100 (mg·kg~(-1)) was injected into peritoneum after model preparation.All rats were sacrificed on 1 hour,1,3 and 7 days after pulmonary thromboembolism, respectively.Arterial blood gas analysis and the level of nitric oxide were measured.The changes in lung morphology were observed by microscopy.Endothelin-1 was assessed by immunohistochemical technique and HMIAS image analysis. Results Thrombi in pulmonary arteries and prominent inflammatory reactions were found by microscopy in model group.The level of NO was significantly decreased,while ET-1 expressions were significantly increased in model group(P(0.01)).After administration of L-Arg,the pathological lesions in lung were relieved with NO level higher than that of the model group,and ET-1 expression lower than that of the model group on 1,3 and 7 days. Conclusion L-Arg may prevent the progress of PTE by increasing NO level and inhibiting expression of ET-1." @default.
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- W2381270878 date "2006-01-01" @default.
- W2381270878 modified "2023-09-28" @default.
- W2381270878 title "Effects of L-arginine on Experimental Pulmonary Thromboembolism" @default.
- W2381270878 hasPublicationYear "2006" @default.
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