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- W2381284127 abstract "UDP-glucuronosyltransferase is an important enzyme involved in the phase II conjugation reaction.UGT is wildly expressed in human liver,kidney,stomach intestine tract and glandular organs.Because of the specificity of its structure and intra-cellular distribution,the study in UGT is lagged behind of the CYP450.Recent two decades,following the progress of the experiment technology,more and more research were focused on the UGT.Following these,the probe drug of UGT are enlarging,it involved in the metabolism of endogenous hormone,drugs and some kinds of toxicity.The polymorphisms of UGT gene were one of the most important reasons lead to the large inter-individual and inter-racial variability of the glucuronodiation activity.There are two subgroups,UGT1A and UGT2,depending on the similarity of the amino acid sequence.This paper reviews the current concept and new advances in the pharmacogenomics of UGT genes which have played an important role in drug metabolism." @default.
- W2381284127 created "2016-06-24" @default.
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- W2381284127 date "2011-01-01" @default.
- W2381284127 modified "2023-09-24" @default.
- W2381284127 title "Progress in the pharmacogenomics of UDP-glucuronosyltransferase" @default.
- W2381284127 hasPublicationYear "2011" @default.
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