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- W2381292832 abstract "Objective:To study the influence and mechanism of Norcantharidin (NCTD) on growth of gastric cancer cell line SGC-7901. Methods: There were NCTD group and control group in the study. The inhibitory rate, cell cycle arrest , apoptosis and morphological changes were detected by MTT assay, flow cytometry and microscope and scan electron microscope, respectively. Results:The inhibitory effect of NCTD on growth of SGC-7901 cells was in a dose-and time-dependent manner. The flow cytometric profiles revealed that the G2/ M phase cells obviously increased and the S phase cells decreased in percentage of SGC-7901 cells , with the increased rate of cell apoptosis. Cell shrinkage ,membrane budding , and karyorrhexis of SGC-7901 cells could been seen by microscope and scan electron microscope. Conclusion: NCTD can inhibit the growth of SGC-7901 cell lines. The mechanism might correlate with inhibition of cell proliferation , blockade of cell cycle , inhibition of DNA synthesis and metabolism and induction of cell apoptosis ." @default.
- W2381292832 created "2016-06-24" @default.
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- W2381292832 date "2008-01-01" @default.
- W2381292832 modified "2023-09-25" @default.
- W2381292832 title "Influence and mechanism of Norcantharidin on growth of gastric cancer cell line SGC-7901" @default.
- W2381292832 hasPublicationYear "2008" @default.
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