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- W2381300582 abstract "Objective To investigate effect of thiol oxidant on Kupffer cell′s activity in actue liver injury.Methods Male mice treated with lipopolysaccharide (LPS) plus D galactosamine (Galn) to develop actue liver injury.Diethylmaleate (DEM),a thiol oxidant,was given ip at the dose of 5 mmol/kg 1 hour before LPS.Levels of plasma ALT,tumor necrosis factor α (TNF α) and GSH in liver and phagocytosis of Kupffer cells were detected.Results Pretreatement with DEM can abrogate the high levels of plasma ALT,TNF α,phagocytosis of Kupffer cells induced by Galn/LPS.Conclusion Thiol oxidant DEM via altering the GSH changes in the liver to influence the cell′s redox state,so as to inhibit the Kupffer cell′s activation induced by LPS,thus alleviating the liver injury." @default.
- W2381300582 created "2016-06-24" @default.
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- W2381300582 date "2004-01-01" @default.
- W2381300582 modified "2023-09-25" @default.
- W2381300582 title "Effect of thiol oxidant on Kupffer cell′s function in actue liver injury" @default.
- W2381300582 hasPublicationYear "2004" @default.
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