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- W2381308849 abstract "Aim To elucidate the plasticity of calcitonin generelated peptidergic(CGRP) nerve fibers in mouse thymus and to provide clues for the roles of immunomodulation of CGRP.Methods Balb/c mice were immunized peritoneally by purified protein from tuberculinderivatives(PPD). Sections of the thymic tissues were treated immunohistochemically and oberserved microscopically. Results In normal group, there were relatively abundant CGRPlike immunoreactive(LI) fibers in capsule and tubercle. A few positive fibers were seen in parenchyma as well. Twenty eight days after PPD immunization, the perivesicular CGRPLI fibers were significantly increased. These fibers were thick in diameter with few buttons and formed reticular structures surrounding blood vessels or bundles going straightly.The CGRPLI fibers in parenchyma of the thymus were slightly increased in number and distributed unevenly. In addition, a few big triangular or ovoid epitheliallike cells in the medulla of thymus were also CGRPLI. Conclusion The present results indicate that CGRP is related to the changes of structure and function of thymus during immune response." @default.
- W2381308849 created "2016-06-24" @default.
- W2381308849 creator A5057774036 @default.
- W2381308849 date "2000-01-01" @default.
- W2381308849 modified "2023-09-23" @default.
- W2381308849 title "Plasticity of calcitonin gene-related peptidergic nerve fibers in the mouse thymus following PPD immunization" @default.
- W2381308849 hasPublicationYear "2000" @default.
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