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- W2381316936 abstract "AIM: To evaluate the pharmacokinetics of satraplatin in rats. METHODS: The drug concentration in plasma,tissues,bile,urine and feces of rats was determined by flameless atomic absorption spectrophotometry. RESULTS: The main pharmacokinetic parameters of satraplatin were: T __ 12β (43± s 34) h and (58±38) h,T _ max (5±2) h and (6±1) h,C _ max (12.6±2.5) mg·L -1 and (13.4±1.5) mg·L -1 ,AUC_ 0-∞ (422±120) mg·h·L -1 and (702±118) mg·h·L -1 for dose of 50 mg·kg -1 and 100 mg·kg -1 , respectively. The distribution process of drug to tissues was quite quicker,liver and kidney had the levels of 15-20 mg·kg -1 ,much higher than the levels of 1-5 mg·kg -1 in other tissues. More than 55 % of the drug was excreted in feces,less than 6 % in urine,0.2 % in bile. CONCLUSION: The drug concentration-time profiles of satraplatin in rats fitted to two compartment modes and show some properties of unlinear pharmacokinetics after oral administration." @default.
- W2381316936 created "2016-06-24" @default.
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- W2381316936 date "2004-01-01" @default.
- W2381316936 modified "2023-09-23" @default.
- W2381316936 title "Pharmacokinetics of oral antitumor drug satraplatin in rats" @default.
- W2381316936 hasPublicationYear "2004" @default.
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