Matches in SemOpenAlex for { <https://semopenalex.org/work/W2381325625> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2381325625 abstract "Objective To investigate the anti-tumor effects of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) on mouse with inoculated myeloma.Methods Thirty-six male BALB/C mice were inoculated with myeloma cells(9.25×109·L-1,0.2 mL) under the skin of left hips.These 36 mice were randomly divided into 6 groups: control group(Group A),high dose intrperitoneal injection group(Group B1),low dose intraperitoneal injection group(Group B2),high dose peri-tumor injection group(Group C1),low dose peri-tumor injection group(Group C2),and preventive high dose intraperitoneal injection group(Group D).Human recombinant TRAIL were given peritoneally or peri-tumor with different doses(high dose,1.5 mg/kg;low dose,0.5 mg/kg) in different group,except for Group A.Tumor size and weight were assessed after 2 weeks,and further observed with HE staining.The cell cycle and apoptosis index of SP2/0 cells were analyzed by flow cytometry.Results Significantly higher efficacy was revealed in Group C than that in Group B,while so was in high dose treatment than low dose.However,no significant superiority was observed in Group D than Group B1.Furthermore,TRAIL induced tumor cell apoptosis in a dose-dependent manner.Conclusion TRAIL can induce apoptosis of SP2/0 cells,inhibit the growth of myeloma.The efficacy is correlated with route of administration and dosage." @default.
- W2381325625 created "2016-06-24" @default.
- W2381325625 creator A5034083482 @default.
- W2381325625 date "2012-01-01" @default.
- W2381325625 modified "2023-09-22" @default.
- W2381325625 title "The anti-tumor effects of TNF-related apoptosis-inducing ligand on myeloma in nude mice" @default.
- W2381325625 hasPublicationYear "2012" @default.
- W2381325625 type Work @default.
- W2381325625 sameAs 2381325625 @default.
- W2381325625 citedByCount "0" @default.
- W2381325625 crossrefType "journal-article" @default.
- W2381325625 hasAuthorship W2381325625A5034083482 @default.
- W2381325625 hasConcept C126322002 @default.
- W2381325625 hasConcept C134018914 @default.
- W2381325625 hasConcept C17991360 @default.
- W2381325625 hasConcept C185592680 @default.
- W2381325625 hasConcept C190283241 @default.
- W2381325625 hasConcept C203014093 @default.
- W2381325625 hasConcept C2776364478 @default.
- W2381325625 hasConcept C2780159080 @default.
- W2381325625 hasConcept C503630168 @default.
- W2381325625 hasConcept C553184892 @default.
- W2381325625 hasConcept C55493867 @default.
- W2381325625 hasConcept C71924100 @default.
- W2381325625 hasConcept C98274493 @default.
- W2381325625 hasConceptScore W2381325625C126322002 @default.
- W2381325625 hasConceptScore W2381325625C134018914 @default.
- W2381325625 hasConceptScore W2381325625C17991360 @default.
- W2381325625 hasConceptScore W2381325625C185592680 @default.
- W2381325625 hasConceptScore W2381325625C190283241 @default.
- W2381325625 hasConceptScore W2381325625C203014093 @default.
- W2381325625 hasConceptScore W2381325625C2776364478 @default.
- W2381325625 hasConceptScore W2381325625C2780159080 @default.
- W2381325625 hasConceptScore W2381325625C503630168 @default.
- W2381325625 hasConceptScore W2381325625C553184892 @default.
- W2381325625 hasConceptScore W2381325625C55493867 @default.
- W2381325625 hasConceptScore W2381325625C71924100 @default.
- W2381325625 hasConceptScore W2381325625C98274493 @default.
- W2381325625 hasLocation W23813256251 @default.
- W2381325625 hasOpenAccess W2381325625 @default.
- W2381325625 hasPrimaryLocation W23813256251 @default.
- W2381325625 hasRelatedWork W2350420545 @default.
- W2381325625 hasRelatedWork W2350656554 @default.
- W2381325625 hasRelatedWork W2354189070 @default.
- W2381325625 hasRelatedWork W2356481950 @default.
- W2381325625 hasRelatedWork W2357355043 @default.
- W2381325625 hasRelatedWork W2362923964 @default.
- W2381325625 hasRelatedWork W2368278869 @default.
- W2381325625 hasRelatedWork W2372595520 @default.
- W2381325625 hasRelatedWork W2376976586 @default.
- W2381325625 hasRelatedWork W2378391618 @default.
- W2381325625 hasRelatedWork W2378628095 @default.
- W2381325625 hasRelatedWork W2382771484 @default.
- W2381325625 hasRelatedWork W2384120296 @default.
- W2381325625 hasRelatedWork W2387930885 @default.
- W2381325625 hasRelatedWork W2389789178 @default.
- W2381325625 hasRelatedWork W2390296156 @default.
- W2381325625 hasRelatedWork W2392475984 @default.
- W2381325625 hasRelatedWork W2491501156 @default.
- W2381325625 hasRelatedWork W2597718923 @default.
- W2381325625 hasRelatedWork W3030508989 @default.
- W2381325625 isParatext "false" @default.
- W2381325625 isRetracted "false" @default.
- W2381325625 magId "2381325625" @default.
- W2381325625 workType "article" @default.