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- W2381327609 abstract "Objective To observe the therapeutic efficacy of intrapleural injection of lentinan combined with IL-2 in the treatment of malignant pleural effusion. Methods 50 patients with malignant pleural effusion were divided into two groups. One group received intrapleural injection of lentinan(group A, n = 25), the other group receive intrapleural injection of lentinan combined with subcutaneous injection of IL-2(group B, n = 25) .The therapeutic efficacy, the changes of tumor cells, performance and immunological criteria and the side reactions were compared between the two groups. Results The therapeutic efficacy, the negative conversion rate of tumor cells and the improvement of performance were significantly higher in group B than in group A( P 0.01) . CD4, CD4/CD8 and the activity of NK cells showed marked elevation in group B as compared with those before treatment( P 0.05) , but no improvement was observed in group A. Conclusion The combined treatment group has better efficacy in treating malignant pleural effusion than the monotherapy group, and has no increase in the side reactions. Hence it is suitable for the elderly and patients with poor general condition." @default.
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- W2381327609 date "2004-01-01" @default.
- W2381327609 modified "2023-09-28" @default.
- W2381327609 title "Clinical study of intrapleural injection of lentinan combined with IL-2 in the treatment of malignant pleural effusion" @default.
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