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- W2381339092 abstract "Objective To study the pharmacokinetics of oral administration of moxifloxacin in Chinese healthy volunteers.Methods The study was designed as an open,randomized,parallel and single-dose cycle study.The volunteers were administered with a single dose of moxifloxacin 400 mg for consistent four days,respectively.The plasma concentrations of moxifloxacin were determined by LC-MS / MS method.The pharmacokinetic parameters of moxifloxacin were calculated by Win Nonlin 5.2.1 software.Results Six subjects quit from the study,and the main pharmacokinetic parameters of the remaining 42 subjects were as follows:t1 /2was(11.71 ± 3.53) h,Cmaxwas(0.51 ± 0.19) × 10-4ng·m L-1,tmaxwas(2.94 ± 1.41) h,MRT0-24 hwas(18.02 ± 4.45) h,CLz /F was(0.84 ± 0.75) × 10-4m L · h-1,AUC0-24 hwas(5.82 ± 1.82) × 10-4ng·m L-1·h.Conclusion The characteristics of oral moxifloxacin 400 mg has shown a high blood concentration,long half-life time and it can be well tolerated.The doses adopted in foreign study is recommended.There was a gender difference in volunteers when with same dose of moxifloxacin." @default.
- W2381339092 created "2016-06-24" @default.
- W2381339092 creator A5046787350 @default.
- W2381339092 date "2015-01-01" @default.
- W2381339092 modified "2023-09-25" @default.
- W2381339092 title "Pharmcokinetics of moxifloxacin in Chinese healthy volunteers" @default.
- W2381339092 hasPublicationYear "2015" @default.
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