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- W2381343670 abstract "【Objective】To study the effect of rosiglitazone(RGZ) on the morphologic change and the expressions of fibroblast-specific protein 1(FSP1) and E-cadherin(E-cad) in HK-2 cells in high glucose medium.【Methods】The third generation cell line of HK-2 were randomly divided into three groups,N Group cultured in 5.5mmol/L glucose,H Group cultured in 25mmol/L glucose,and HR Group cultured in 25mmol/L glucose and 10μmol/L RGZ.The morphology was observed by light microscopy and electron microscopy.The expressions of protein level of FSP1 and E-cad were tested by Western blot,respectively.【Results】①Compared with N Group,the cells in H Group were fusiform shape,and under electron microscope,rough endoplasmic reticulum(RER) significantly increased,and mitochondria and microvilli decreased,and the protein expression of FSP1 increased(P0.01),but those of E-cad decreased(P0.01).②Compared with H Group,the cells treated with RGZ were polygon and round,and under electron microscope,mitochondria and microvilli increased and RER decreased,and the protein level of FSP1 decreased(P0.01),but the protein level of E-cad increased(P0.01).【Conclusion】①HK-2 stimulated by high glucose displays transdifferentiation of renal tubular epithelial cell.②RGZ can attenuate transdifferentiation of HK-2 stimulated by high glucose." @default.
- W2381343670 created "2016-06-24" @default.
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- W2381343670 date "2008-01-01" @default.
- W2381343670 modified "2023-09-24" @default.
- W2381343670 title "Effect of PPARγ Agonists on the Morphologic Change and the Expressions of FSP1 and E-cad in Human Renal Tubule Cells Cultured in High Glucose Medium" @default.
- W2381343670 hasPublicationYear "2008" @default.
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