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- W2381375265 abstract "Objective To investigate the inhibitory effects of hepatitis B virus( HBV) S gene-specific anti-gene locked nucleic acid( LNA) on HBV replication and expression in hepG2. 2. 15 cells. Methods The anti-gene LNA which were complementary to the purine rich region of the HBV S gene was synthesized and transfected into HepG22. 2. 15 cells by cationic liposomes. The HBsAg,HBeAg and HBV DNA of supernatants were tested by time-resolved fluorescence immune Assay( TRFIA) and real-time fluorescent quantitative polymerase chain reaction( FQPCR) at 2,4,6,8 and 10 d after treatment. LNA's cyto-toxicity on cell was evaluated by methyl thiazolyl tetrazolium( MTT) method. Results The anti-gene LNA targeting at the purine rich region of HBV S gene showed significantly inhibitory effects on replication of HBV DNA and the expression of HBsAg and HBeAg with the inhibition rates of 52. 14%,57. 48% and 29. 63% respectively after 6 days. There's no obvious toxicity on cell. Conclusions Anti-gene locked nucleic acid targeting at the purine rich region of HBV S gene has shown significant inhibition on HBV in vitro. It has a therapeutic potential for the treatment of patients infected with HBV." @default.
- W2381375265 created "2016-06-24" @default.
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- W2381375265 date "2014-01-01" @default.
- W2381375265 modified "2023-09-28" @default.
- W2381375265 title "Anti-gene locked nucleic acid( LNA) inhibits HBV S gene expression in vitro" @default.
- W2381375265 hasPublicationYear "2014" @default.
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