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- W2381397239 abstract "Objective To assess the clinical efficacy and safety of high-dose methylprednisolone (MP) and biological agent infliximab in ankylosing spondylitis (AS). Methods We retrospectively analyzed 48 cases of AS. In MP treatment group, 27 patients were treated with 250-500mg per day, intravenous for 3-4 days a week, repeated a times, treated for 3 times, then given prednisone 20mg per day to maintain. After 6 weeks, prednisone was gradually reduced and finally removed the prednisone 20 weeks later. In infliximab treatment group, 21 patients were given intravenous infliximab 0.2 on the zero and second week. We assessed patients respectively before treatment and on the third week after treatment. We considered the proportion of ASAS20 as the primary efficacy endpoint, and ASAS40 as the secondary efficacy endpoint. Results All patients completed treatment. The MP treatment group and the infliximab treatment group had a more rapid improvement in other indexes of the efficacy and laboratory (p 0.05). The groups had a more rapid improvement in ASAS20 and ASAS40 after the 3 weeks (81.48% Vs 80.95%, 59.26% Vs 66.67%, p0.05, respectively). During the treatment 9 patients (33.33%) in the glucocorticoid treatment group and 5 patients (23.8%) occurred adverse events with treatment-related. All adverse events were moderate, temporary, and gradually appeared with symptomatic treatment. Conclusion High-dose MP and infliximabcan improved the symptoms, signs, inflammatory indexes, home range and quality of life of AS short-term significantly and rapidly, MP can make up some questions such as taboo and expensive about treatment using infliximab, and is a cheap medicine relatively. But we still need further study about MP improving the condition of AS." @default.
- W2381397239 created "2016-06-24" @default.
- W2381397239 creator A5073026249 @default.
- W2381397239 date "2010-01-01" @default.
- W2381397239 modified "2023-09-24" @default.
- W2381397239 title "The short-term clinical observation of intravenous methylprednisolone pulses and biological agent infliximab in the management of ankylosing spondylitis" @default.
- W2381397239 hasPublicationYear "2010" @default.
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