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- W2381414501 abstract "Objective: To study the role of genitofemoral nerve(GFN) in INSL3 gene expression in the testes of unilateral cryptorchidim in rats.Methods: Male Sprague-Dawley rats were divided into four groups: group A(n=12),unilateral cryptorchidism;group B(n=12),unilateral cryptorchidism combined with GFN division at 30 days old;group C(n=10),bilateral cryptorchidism;and group D(n=10),control group.The cryptorchidism model was established by 17-β estradiol.Samples of blood plasma of all groups were collected after eight weeks and radioimmunoassay of testosterone,E_2,LH and FSH was performed.At the same time,the rats' testes were surgically removed and total RNA was extracted with trazol.The expression of INSL3 gene was delected by RTPCR and Northern blot.Results: Compared with group D,levels of serum testosterone in group A,B and C decreased obviously(P0.05),serum LH in group A and B increased,but in group B was obviously higher than in group A(P0.05).The lower INSL3 mRNA found in unilateral undescended testis (UUDT) in group A and B than in group D.However,the contralateral descended testis(CDT) in group B was obviously higher than in group A.(Conclusion:) The INSL3 gene expression decreaded in testes of unilateral cryptorchidism.An intimate relationship exists between genitofemoral nerve and the lower INSL3 mRNA.The reason of damage of spermatogenesis function in the contralateral descended testis CDT probably comes from genitofemoral nerve." @default.
- W2381414501 created "2016-06-24" @default.
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- W2381414501 date "2006-01-01" @default.
- W2381414501 modified "2023-09-25" @default.
- W2381414501 title "Role of Genitofemoral Nerve in INSL3 Gene Expression in Rat Testes of the Unilateral Cryptorchidism" @default.
- W2381414501 hasPublicationYear "2006" @default.
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