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- W2381423869 abstract "【Objective】 To study the influence of calcium gene-related peptide(CGRP) on endothelin(ET) and free calcium concentration in brain cells of hypoxic-ischemic neonatal SD(Spraque-Dawley) rats. 【Methods】 The 45 SD rats of 7 days were divided into three groups randomly. In CGRP group , the rats were given CGRP intraperitoneally for 3 days in doses of 3 μg/(kg·d) putting into natural salt 2 ml once the hypoxic-ischemic encephalopathy(HIE) model was made; In natural salt group , the rats were given natural salt in doses of 2 ml/d intraperitoneally for 3 days and the rats were treated with pseudo operation in normal group . All the rats were decapitated after three days, and the concentration of ET and free calcium in brain cells were measured with radioimmunoassay and calcium fluorescence indicator in Fura-2Am. 【Results】 The concentration of ET and free calcium in brain cells of natural salt group[(93.41±12.73)ng/L and(129.47±17.21)nmol/L respectively ] were higher than those of normal group [(57.58±6.31)ng/L and(93.72±24.16)nmol/L ] and CGRP group [(61.68±6.83)ng/L and(103.35±12.46)nmol/L] significantly (P0.01), but there was no significant difference between CGRP group and normal group (P0.05). 【Conclusions】 CGRP can antagonize the vasoconstriction of ET and improve brain circulation,so it inhibits synthesis and release of ET. In addition, it can prevent calcium from flowing into brain cells, and protect hypoxic-ischemic cerebral injury." @default.
- W2381423869 created "2016-06-24" @default.
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- W2381423869 date "2005-01-01" @default.
- W2381423869 modified "2023-09-24" @default.
- W2381423869 title "Influence of calcium gene-related peptide on endothelin and free calcium concentration in brain cells of hypoxic-ischemic neonatal SD rats." @default.
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