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- W2381428630 abstract "The immune enhancement of the unmethylated CpG oligonucleotides(CpG ODNs) on inactivated Newcastle disease virus(NDV) vaccine was investigated in chickens.In the lymphocyte proliferation assay,CpG ODN2007 induced a significant stimulatory effect on cell proliferation even at low concentrations.Subsequently,chickens were immunized with different doses of inactivated NDV supplemented with CpG ODN2007.Blood samples were collected to measure antibody titers and cell mediated immune response.Then,chickens were challenged with virulent NDV.As a result,chickens immunized with NDV plus CpG ODN2007 showed a significantly enhanced antibody response in comparison with the control group that received equal doses of NDV alone.The antibody titers and protection against virulent virus challenge in the chickens immunized with 1/10 dose of NDV plus CpG ODN2007 were comparable with those immunized with the highest dose of NDV alone.The present study demonstrated the immune enhancement of CpG ODN on immune responses of inactivated NDV vaccine in chickens." @default.
- W2381428630 created "2016-06-24" @default.
- W2381428630 creator A5059712495 @default.
- W2381428630 date "2010-01-01" @default.
- W2381428630 modified "2023-09-24" @default.
- W2381428630 title "ENHANCEMENT OF CPG ODN ON IMMUNE RESPONSES OF INACTIVATED NEWCASTLE DISEASE VIRUS VACCINE" @default.
- W2381428630 hasPublicationYear "2010" @default.
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