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- W2381459940 abstract "Objective To investigate the mechanism of fluvastatin on the expression of TGF-β and fibronectin( FN) in human perito-neal mesothelial cells( HPMC) induced by high-glucose peritoneal dialysate( HGPDS). Methods HPMC are divided into groups as normal control group,high glucose dialysate group,high glucose dialysate plus fluvastatin group. RT-PCR was used to identify the mRNA expression of PPAR-,TGF-β1,Collagen I( Col I),FN. The levels of FN in culture media were measured by ELISA. Results PPAR-,TGF-β1,Col I,FN mRNA expression induced by high glucose measured by RT-PCR in HPMC increased highest level at 12 hours. Compared with high glu-cose peritoneal dialysate group,the fluvastatin can decrease the expression of PPAR-,TGF-β1,Collagen I,Fibronectin mRNA and Fibronectin protein caused by high glucose. There was significant difference( P 0. 01). Conclusion Fluvastatin could decrease the high expression of PPAR-,TGF-β1,Col I,FN induced by HGPDS." @default.
- W2381459940 created "2016-06-24" @default.
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- W2381459940 date "2013-01-01" @default.
- W2381459940 modified "2023-09-23" @default.
- W2381459940 title "The mechanism investigation of fluvastatin inhibits the expression of fibronectin and TGF-β in human peritoneal mesothelial cells in-duced by high-glucose peritoneal dialysate" @default.
- W2381459940 hasPublicationYear "2013" @default.
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