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- W2381469971 abstract "Objective To study the effect of immune regulation of the rat Sertoli cells in testis infection. Methods UU and Escherichia coli (E.coli) were injected into the bladders of rats, which mimic the ascending infection pathway, culture medium injection was used as control. After 1, 2, and 3 weeks respectively, Sertoli cells were separated and obtained from rat testis. RT PCR was used to examine the different levels of IL 1, IL 6 mRNA among control ,UU and E.coli infected groups. Results Compared with control, in UU group, the level of IL 1 mRNA was significantly increased at 1, and 2 weeks, but were significantly decreased at 3 weeks; the level of IL 6 mRNA was significantly decreased at 1 and 2 weeks, but were significantly increased at 3 weeks. In E.coli group, the level of IL 1mRNA was significantly increased at 1 week, slightly increased at 2 weeks, but significantly decreased at 3 weeks; the level of IL 6 mRNA was significantly increased at 1 week, slightly decreased at 2 weeks, significantly increased again at 3 weeks. Conclusion Sertoli cell could play a role of immune regulation, with the expression of IL 1, IL 6mRNA, in the infection of testis in rat. [" @default.
- W2381469971 created "2016-06-24" @default.
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- W2381469971 date "2002-01-01" @default.
- W2381469971 modified "2023-09-25" @default.
- W2381469971 title "Immunoregulative mechanism of the Sertoli cell in testis infection by expression of IL-1 and IL-6 mRNA" @default.
- W2381469971 hasPublicationYear "2002" @default.
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