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- W2381471070 abstract "Objective:To develop an LC-MS/MS method for the simultaneous determination of trimebutine(TM) and N-monodemethyltrimebutine(N-TM) concentration in dog plasma to study the pharmacokinetics of TM maleate in healthy Beagles.Method:The analytes were extracted from plasma samples by liquid-liquid extraction and sibutramine was selected to be the internal standard.Detection was carried out on a triple quadrupole tandem mass spectrometer in multiple reactions monitoring(MRM) mode using positive electrospray ionization(ESI).The ion combination of m/z 388.2→m/z 343.2,m/z 374.2→m/z 195.2,m/z 280.3→m/z 125.1 was used to qualify TM,N-TM and the internal standard,respectively.After a single oral dose of 300 mg TM,the concentrations of TM and N-TM were detected and the pharmacokinetic parameters were calculated by DAS 2.0.Result:The calibration curve was in good linearity over the range of 1-500 ng·mL-1(r=0.9959) for TM and 0.2-100 ng·mL-1(r=0.9951) for N-TM.The intra-day and inter-day precisions(RSD) were lower than 10% and the extraction recovery was higher than 85% for both determined compounds.The main pharmacokinetic parameters of Cmax,Tmax and T1/2 were(192±32.1)ng·mL-1,(0.667±0.258)h,(10.8±4.27)h for trimebutine(47.1±22.6)ng·mL-1,(1.08±0.492)h,7.06±2.53 h for N-TM,respectively.Conclusion:The method is shown to be simple,accurate,sensitive and specific for the simultaneous determination of TM and N-TM in Beagles plasma and can be used for the pharmacokinetic study." @default.
- W2381471070 created "2016-06-24" @default.
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- W2381471070 date "2012-01-01" @default.
- W2381471070 modified "2023-09-25" @default.
- W2381471070 title "LC-MS/MS simultaneous determination and pharmacokinetics of trimebutine and it's metabolite in Beagle plasma" @default.
- W2381471070 hasPublicationYear "2012" @default.
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