Matches in SemOpenAlex for { <https://semopenalex.org/work/W2381485953> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W2381485953 abstract "Objective It is to discuss the establishing method of atherosclerosis (AS) rat model with coagulation of phlegm and blood stasis syndrome.Methods 100 12-week-old male Wistar rats were randomly divided into normal group(N,n=20),model group(M,n=20),dissipate phlegm group(T,n=15),removing blood stasis group(Y,n=15),phlegm and blood stasis both treated low dosage group(TYD,n=15) and phlegm and blood stasis both treated high dosage group(TYG,n=15).Group N was fed with foundation stoyer for 12 weeks.After intraperitoneal injected with single dose of vitamin D3(400 000 IU/kg) and were fed with high fat stoyer for six weeks,the rest five groups were respectively treated with normal saline(10 mL/(kg·d)),dissipate phlegm liquid extract(0.16 g/mL),removing blood stasis liquid extract(0.2 g/mL),phlegm and blood stasis both treated liquid extract(0.8 g/mL) and phlegm and blood stasis both treated liquid extract(1.6 g/mL) intragastric administration for six weeks.After establishing model for two and six weeks,five rats from control group and five rats from model group were detected blood fat and hemorheology,total length aorta and heart of the ten rats were got and the affection grading score was carried out with oil red O staining method,and the patho-morph changes of plaque in the ten rats were observed with HE staining method.After intragastric administration treatment for six weeks,all the rats were put to death and done the same way.Results After establishing model for two weeks,the level of blood fat of group M was risen(P0.05).After six weeks,blood fat level increased continuously with hemorheology index rising(P0.05),the score of the aorta affection was obviously increased(P=0.001) and the typical scleratheroma plaque in aorta and coronary artery was seen under light microscope.After intragastric administration for six weeks,the levels of blood fat and hemorheology index in the treatment groups were all decreased(P0.01),the scores of the aorta affection were obviously decreased than that in group M(P0.01) but a little higher than that in group N(P0.05) and the degree of AS affection under light microscope was obviously lightened than that in group M.Especially group TYD and group TYG had obvious changes,and there was significant difference between the two groups(P0.05).Conclusion After calcium over loading method with intraperitoneal injected with single dose of vitamin D3 400 000 IU and fed with high fat stoyer for six weeks,AS rat model with coagulation of phlegm and blood stasis syndrome is established." @default.
- W2381485953 created "2016-06-24" @default.
- W2381485953 creator A5071909952 @default.
- W2381485953 date "2007-01-01" @default.
- W2381485953 modified "2023-09-25" @default.
- W2381485953 title "Establishment of atherosclerosis rat model with coagulation of phlegm and blood stasis syndrome" @default.
- W2381485953 hasPublicationYear "2007" @default.
- W2381485953 type Work @default.
- W2381485953 sameAs 2381485953 @default.
- W2381485953 citedByCount "0" @default.
- W2381485953 crossrefType "journal-article" @default.
- W2381485953 hasAuthorship W2381485953A5071909952 @default.
- W2381485953 hasConcept C126322002 @default.
- W2381485953 hasConcept C142724271 @default.
- W2381485953 hasConcept C188947578 @default.
- W2381485953 hasConcept C204787440 @default.
- W2381485953 hasConcept C2776379591 @default.
- W2381485953 hasConcept C2777397205 @default.
- W2381485953 hasConcept C2778731716 @default.
- W2381485953 hasConcept C2779980429 @default.
- W2381485953 hasConcept C2780159080 @default.
- W2381485953 hasConcept C71924100 @default.
- W2381485953 hasConcept C78520924 @default.
- W2381485953 hasConcept C90924648 @default.
- W2381485953 hasConceptScore W2381485953C126322002 @default.
- W2381485953 hasConceptScore W2381485953C142724271 @default.
- W2381485953 hasConceptScore W2381485953C188947578 @default.
- W2381485953 hasConceptScore W2381485953C204787440 @default.
- W2381485953 hasConceptScore W2381485953C2776379591 @default.
- W2381485953 hasConceptScore W2381485953C2777397205 @default.
- W2381485953 hasConceptScore W2381485953C2778731716 @default.
- W2381485953 hasConceptScore W2381485953C2779980429 @default.
- W2381485953 hasConceptScore W2381485953C2780159080 @default.
- W2381485953 hasConceptScore W2381485953C71924100 @default.
- W2381485953 hasConceptScore W2381485953C78520924 @default.
- W2381485953 hasConceptScore W2381485953C90924648 @default.
- W2381485953 hasLocation W23814859531 @default.
- W2381485953 hasOpenAccess W2381485953 @default.
- W2381485953 hasPrimaryLocation W23814859531 @default.
- W2381485953 hasRelatedWork W2034549003 @default.
- W2381485953 hasRelatedWork W2075558315 @default.
- W2381485953 hasRelatedWork W2347262933 @default.
- W2381485953 hasRelatedWork W2349695233 @default.
- W2381485953 hasRelatedWork W2354221983 @default.
- W2381485953 hasRelatedWork W2356214656 @default.
- W2381485953 hasRelatedWork W2357794995 @default.
- W2381485953 hasRelatedWork W2357987145 @default.
- W2381485953 hasRelatedWork W2371304276 @default.
- W2381485953 hasRelatedWork W2373557755 @default.
- W2381485953 hasRelatedWork W2373764446 @default.
- W2381485953 hasRelatedWork W2375913472 @default.
- W2381485953 hasRelatedWork W2379239945 @default.
- W2381485953 hasRelatedWork W2380436343 @default.
- W2381485953 hasRelatedWork W2385965101 @default.
- W2381485953 hasRelatedWork W2390119123 @default.
- W2381485953 hasRelatedWork W2392179038 @default.
- W2381485953 hasRelatedWork W2392868877 @default.
- W2381485953 hasRelatedWork W2408681590 @default.
- W2381485953 hasRelatedWork W3030797851 @default.
- W2381485953 isParatext "false" @default.
- W2381485953 isRetracted "false" @default.
- W2381485953 magId "2381485953" @default.
- W2381485953 workType "article" @default.