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- W2381520504 abstract "Objective To develop a simple and economic method to establish type 2 diabetes Sprague-Dawley rats model.Methods SD rats(200±10) g were admisnistrated intragastrically with high fat,cholesterol and sugar to induce,Insulin Resistance,then the uptake of food,water,and body weight changes were recorded.After 3 months of dietary manipulation,the rats were injected intraperitoneally with low dose of streptozotocin(STZ,20 mg/kg)two times and fed to high-fat diet for another 2 months to establish type 2 diabetes rats model.The body weitht(BW),the serum levels of FGLU,FMN,INS,C-P,CRP,TG,and TCHOL were detected,and Insulin Resistance Index(IRI)was calculated.Results The HFD+STZ rats exhibited significant increase in FGLU,FMN,INS,C-P,CRP,TG,TCHOL,and IRI,compared with HFD group(P0.05),the HFD group exhibited significant increase in these indicators,compared with normal group(P0.05).Intraperitoneal injection of low dose of streptozotocin(STZ,20 mg/kg)two times had less toxicity,and the success rate of establishing type 2 diabetes SD rats model reached 90%.Conclusions Intragastric administration of high-fat and cholesterol plus intraperitoneal injection of low dose of streptozotocin two times can establish type 2 diabetes rats model.The model can simulate natural disease progression and metabolic characteristics of type 2 diabetes,and has characteristics of hyperinsulinism and insulin resistance,therefore it can be as an ideal animal model for type 2 diabetes research." @default.
- W2381520504 created "2016-06-24" @default.
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- W2381520504 date "2010-01-01" @default.
- W2381520504 modified "2023-09-25" @default.
- W2381520504 title "Induction of Type 2 Diabetes SD Rats Model with Intragastric Administration of High-fat and Cholesterol" @default.
- W2381520504 hasPublicationYear "2010" @default.
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