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- W2381526948 abstract "Objective: To investigate the dynamic expressions of endocannabinoid receptors(CB1,CB2) in the livers of rats with non-alcoholic fatty liver disease(NAFLD) and explore the role of endocannabinoid receptors in the pathogenesis of NAFLD in rats.Methods: An experimental rat model of NAFLD was established by feeding rats with high fat diet.The rats were euthanized at the 8,16 and 24 weeks.Hepatic steatosis,inflammation activity and fibrosis degree were observed by routine HE staining.The expression of CB1 and CB2 in the livers were determined by immunohistochemistry at different NAFLD stages.Results: The experimental rats exhibited simple fatty 1iver at 8 weeks,diffuse hepatic steatosis with inflammatory cell infiltration at 16 weeks,and at 24 weeks hepatic steatosis was still present while the degree of inflammation reduced and with different grade of fibrosis.CB1 and CB2 were not expressed in the livers of normal rats,however,the expressions of CB1 and CB2 were significantly increased in the livers of experimental rats.The expression of CB1 was higher than that of CB2 at 8 and 24 weeks.Conclusion: The expression of CB1 and CB2 is significantly increased in the livers of rats with NAFLD,and may play an important role in the pathogenesis of NAFLD." @default.
- W2381526948 created "2016-06-24" @default.
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- W2381526948 date "2011-01-01" @default.
- W2381526948 modified "2023-09-24" @default.
- W2381526948 title "The dynamic expressions of endocannabinoid receptors in livers of rats with non-alcoholic fatty liver disease" @default.
- W2381526948 hasPublicationYear "2011" @default.
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