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- W2381528080 abstract "Objective To explore the method for intraoperative confirming target localization accuracy in deep brain stimulation(DBS).Methods Experience of intraoperative target localization for DBS in 146 patients with Parkinson disease(PD) undergoing unilateral(n=70) or bilateral(n=76) subthalamic nucleus stimulation were analyzed retrospectively.Before the operation,the target coordinates were calculated by direct MRI neuroimaging and coordinates.During the operation,extracellular discharge was recorded by a microelectrode,and the target localization accuracy was confirmed by observing the micro-ablative effect,stimulating effect,side effect,and by X-ray and MRI examinations.Results Micro-ablative effect was observed in 76 of 112 hypermyotonia,44 of 91 tremor and 40 of 109 bradykinesia patients after electrode implantation.During stimulation,symptoms were relieved in 103 of 106 hypermyotonia,64 of 86 tremor and 69 of 109 bradykinesia patients.1.0 to 3.5V test stimulation caused mild side effects in 27 patients.Obvious side effects were observed in 126 patients receiving 3.5 to 10.0V test stimulation,among them 3 required changing the target coordinates because of low threshold of side effect.C-arm X-ray set was used in 16 patients,showing the electrodes were too deep-seated in 4.The electrodes were too deep-seated in 16 and too medial in 3 of 87 cases rechecked by MRI.Conclusion Accuracy of stereotactic electrode placement can be confirmed by observation of micro-ablative effects,test stimulation-induced effects and side-effects.Intraoperative MRI with stereotactic frame can replace the microelectrode recording and reduce hemorrhage and reoperation." @default.
- W2381528080 created "2016-06-24" @default.
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- W2381528080 date "2009-01-01" @default.
- W2381528080 modified "2023-09-24" @default.
- W2381528080 title "Method for intraoperative confirming target localization accuracy in deep brain stimulation" @default.
- W2381528080 hasPublicationYear "2009" @default.
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