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- W2381532864 abstract "Objective:To investigate the mechanisms of Yi-Qi Huo-Xue therapy(YQHX)by observing its effects on expressions of the mRNA of vascular endothelial growth factor (VEGF)and the receptors Flt-1, Flk-1 in intracerebral hemorrhagic(ICH)rat brains.Methods:ICH was induced by injecting collagenase type Ⅶstereotaxically into rat brain right globus pallidus. One hundred and fifty-five Sprague-Dawley rats were randomly divided into six groups, including normal control group(n=5), sham group(n=30), ICH model group(n=30), YQHX-treated group(n=30),YiQi-treated group(n=30)and HuoXue-treated group(n=30),respectively administered orally with the classic YQHX prescription,Buyanghuanwu decoction, its YiQi and Huo xue components, all at the dosage three times that of a 70kg adult; The expression of mRNA of VEGF, FLT-1 and Flk-1 was assayed by reverse transcription-polymerase chain reaction(RT-PCR)at day 1、4、7、14、21 and 28 after the onset. Results:Nonsignifficant expression of VEGF mRNA in rat brains of normal or sham during the experiment; In model group, the expressions of VEGF mRNA、Flt-1mRNA and Flk-1mRNA appeared at 1d, peaked at 21d, and then weakened gradually; The expressions of VEGF mRNA、Flt-1mRNA and Flk-1mRNA in YQHX-treated group were significantly higher than those in the other groups from 7d to 21d,and the expression of VEGF mRNA and Flk-1mRNA in YQHX-treated group reached peak at 14d, but the expression of Flt-1mRNA reached at 21d.Conclusions:The Yi-Qi Huo-Xue therapy can promote the expressions of VEGFmRNA、Flt-1mRNA and Flk-1mRNA in intracerebral hemorrhagic rats, which may be related with its promoting the reconstruction of the microvascular networks in the damaged zone." @default.
- W2381532864 created "2016-06-24" @default.
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- W2381532864 date "2007-01-01" @default.
- W2381532864 modified "2023-09-23" @default.
- W2381532864 title "Effect of Yi-Qi Huo-Xue Therapy on Expression of VEGF and its Receptors Flt-1,Flk-1 mRNA in Rat Brains Following Intracerebral Hemorrhage" @default.
- W2381532864 hasPublicationYear "2007" @default.
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