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- W2381535237 abstract "Objective To evaluate the therapeutic effects of CsA combined with allogenic hepatocyte through intrasplenic transplantation on rats with acute hepatic failure.Methods Acute hepatic failure(AHF) rats were induced by 350 mg/kg thioacetamide(TAA)and randomly divided into 3 groups 24 h after intoxication.Rats in Group I received 1ml of approximately 2×107 hepatocytes suspension and CsA 10 mg/(kg.d),through intrasplenic injection and intramuscular injection.Rats in Group Ⅱ only received 1 mL of approximately 2×107 hepatocytes suspension.Rats in Group Ⅲ as control received 1 ml of normal saline.The survival rate,hepatic biochemical function and pathological changes of transplanted hepatocytes and liver of all rats were observed.Results One-week survival rate in group Ⅰ and group Ⅱ was higher than that of group Ⅲ(64.7% vs 12.5%,P 0.01;and 56.3% vs 12.5%,P 0.01,respectively),while there was no significant difference in one-week survival rate between group Ⅰ and group Ⅱ(64.7% vs 56.3%,P0.05).Hepatic function and liver pathological state of rats were improved significantly in group Ⅰ and group Ⅱ,especiall in group I.Conclusion CsA combined with allogenic hepatocyte transplantation can effectively treat rats with acute hepatic failure,improve the survival rate of rats,and ameliorate hepatic function and hepatic pathological state." @default.
- W2381535237 created "2016-06-24" @default.
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- W2381535237 date "2011-01-01" @default.
- W2381535237 modified "2023-09-25" @default.
- W2381535237 title "Therapeutic Effects of CsA Combined with Hepatocyte Intrasplenic Transplantation on Acute Hepatic Failure" @default.
- W2381535237 hasPublicationYear "2011" @default.
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