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- W2381552420 abstract "Objective To investigate the expression of MRP gene and its relation to pathological features of esophageal and cardiac cancer. Methods RT-PCR was applied to study expression of MRP gene in tumor tissues from 83 cases of esophageal and cardiac carcinoma, and 45 lymph nodes from 28 patients. Results The positive rate for MRP in esophageal and cardiac cancer (31.4%, 16.7%) differed significantly from their paracancerous tissue (5.7%, 2%) (P 0. 01). 6 were positive for MRP expression out of 28 metastatic lymph nodes (23. 1%), while no MRP expression was found in 19 nonmetastatic lymph nodes. In deeper muscles invaded with tumor tissue and TNM, expression of MRP gene was higher than in non-invasive and superficial muscles. And the positive rates for MRP in tumors at stages of III and IV (26.6%, 28.8%) were higher than those at the stages of I and II (10. 5 % , 12.9%). The expression of MRP was stronger in less differentiated tumors. In addition, in a follow-up of 48 cases for a period of one or two years, it was found that recurrence and metastasis were more frequent in tumors with positive MRP expression than with negative MRP expression (P0. 05). Conclusions Overexpression of MRP gene in tumor tissues of esophageal and cardiac carcinoma was consistent with the expression of MRP in metastasis in lymph nodes. The positive MRP gene indicated not only multiple-drug resistance, but also a poor prognosis." @default.
- W2381552420 created "2016-06-24" @default.
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- W2381552420 date "2000-01-01" @default.
- W2381552420 modified "2023-09-25" @default.
- W2381552420 title "Relationship between expression of MRP gene and pathological features of esophageal and cardiac carcinoma" @default.
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