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- W2381554717 abstract "Objective To investigate the effects of auranofin (AF) on apoptosis of neutrophils. Methods Neutrophils were incubated with various concentrations of AF for different periods. Cell viability was determined by the MTS assay and apoptosis was evaluated by flow cytometric analysis of propidium iodide (PI)-staining of the nuclei and annexin-V staining of phosphatidylserine in the cell membrane. Results At a low concentration (1 μmol/L), AF significantly prolonged neutrophil survival by delaying spontaneous apoptosis. In contrast, a higher AF concentration (5μmol/L) shortened neutrophil survival by the induction of cell necrosis. Conclusion The serum concentration of AF in patients with rheumatoid arthritis is about 0.7μmol/L, in which neutrophils are prolonged their functional life-span through delaying the spontaneous apoptosis. Thus, it seems to be unlikely that AF exerts the anti-inflammatory effect in vivo by directly suppressing neutrophil functions. The therapeutic benefit of AF in rheumatoid arthritis may be mediated in a complex manner." @default.
- W2381554717 created "2016-06-24" @default.
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- W2381554717 date "2003-01-01" @default.
- W2381554717 modified "2023-09-24" @default.
- W2381554717 title "Effect of auranofin, an antirheumatoid drug, on neutrophil apoptosis" @default.
- W2381554717 hasPublicationYear "2003" @default.
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