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- W2381556543 abstract "Objective To investigate the relationship between Ca 2+ channels and the function of detrusor in rats. Methods A total of 38 rats were divided into stable(29 cases) and instable(9 cases) groups according to the changes of cystometric studies. The bladder outlet obstruction models(11 cases) and L1 2 level spinal cord injury models(9 cases) were established with rats in the stable group. The mRNA expressions of L and T type Ca 2+ channels in the detrusor of different groups were measured by RT PCR. Results The occurrence rate of detrusor instability was 24 3% in normal rats. Both L and T type Ca 2+ channels were found in rat detrusor, and the expressions in instable, BOO and SCI groups were much higher than that of control. The increase in the expression of T type Ca 2+ channel was more obvious. Conclusion The up regulation of calcium channels, especially T type Ca 2+ channel, may be the key factor to lead to detrusor instability." @default.
- W2381556543 created "2016-06-24" @default.
- W2381556543 creator A5026024648 @default.
- W2381556543 date "2003-01-01" @default.
- W2381556543 modified "2023-10-12" @default.
- W2381556543 title "Expressions and changes of Ca~(2+) channels in detrusor instability in rats" @default.
- W2381556543 hasPublicationYear "2003" @default.
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