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• W2381566818 abstract "Objective:To study the preventive and therapeutic effects of continuous lumbar epidural block in rats with hypertensive disorder complicating pregnancy. Methods:The rat model of hypertensive disorder complicating pregnancy was established according to Olson's method in 40 Wistar rats. The rats were injected with normal saline subcutaneously in group A,L-NAME subcutaneously in group B,and Bupivacaine epidurally in group D. The rats in group C received no drug. The body weight,food intake,urine volume,and water intake were recorded on days 13 and 20 of gestation. The blood pressure was monitored with tail-cuff method from day 13 of the gestation. The urine protein content and the levels of nitric oxide in the uterus and placenta on days 13 and 20 of gestation were determined by sulfosalicylic acid test and nitric acid reductase method,respectively. Results:On day 20 of gestation,compared with groups A and D,the body weight increased and the food intake and urine volume decreased in groups B and C (all P 0.01),but no significant difference in water intake was found. The systolic blood pressure and heart rate in groups B and C were significantly higher than those in groups A and D on day 20 of gestation,and the heart rate in group A was significantly higher than that in group D (all P 0.01). The urine protein content in groups B,C,and D was significantly higher than that in group A on day 20 of gestation,and in groups B and C it was significantly higher than that in group D (all P 0.01). Compared with groups A and D,the survival rate and the level of nitric oxide significantly decreased in groups B and C (P 0.01). Conclusion:The continuous lumbar epidural block may have preventive and therapeutic effects in rats with hypertensive disorder complicating pregnancy." @default.
• W2381566818 created "2016-06-24" @default.
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• W2381566818 date "2007-01-01" @default.
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• W2381566818 title "Preventive and therapeutic effects of continuous lumbar epidural block in rats with hypertensive disorder complicating pregnancy" @default.
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