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- W2381567365 abstract "Objective To investigate the change of CD4+CD25+T cells in bronchoalvelar lavage fluid (BALF),blood and spleen of asthmatic rat and the effect of dexamethasone on CD4+CD25+T cells.Methods Fifty SD rats were randomly divided into five groups with 10 rats in each group:control group(A),asthmatic group(B),dexamethasone low-dose group (C),dexamethasone mid-dose group (D),dexamethasone high-dose group (E).Group A was established by saline.The rat was injected saline 1 ml in 1 day and challenged from days 15 to 21 by saline 10 ml.The group B,C,D,E,were sensitized on days 1 by injected OVA 1mg and 1% OVA aerosol challenged from days 15 to 21.The group C,D,E were injected dexamethasone(0.2 mg/kg,1 mg/kg,2 mg/kg) after challenges 30 minutes.CD4+CD25+T cells in BALF,blood and spleen are measured by flow cytometric analysis.Results BALF,blood and spleen's ratio of CD4+CD25+T cells to CD4+T cells of group B were significantly higher than those in group A[(42.21±5.62)% vs (18.76±5.85)%,P0.01],[(12.69±2.70)% vs (6.27±1.73)%,P0.01],[(11.15±1.05)% vs (7.85±2.13)%,P0.05].In BALF,group C(10.49±4.03)%,group D(13.28±5.12)%,group E (7.51±5.3)%,compared with group A(18.76±5.85)% group B(42.21±5.62)%,the differences were significant (all P0.05).In blood,group C(6.03±1.43)%,group D(4.88±0.95)%,compared with group A(6.21±1.73)%,the differences were no significant.Group E(3.49±0.62)%,compared with group A(6.21±1.73)%,group C(6.03±1.43)%,the differences were significant,(all P0.05).In spleen,group C (7.25±1.82)%,group D(8.63±3.18)%,compared with group A(7.85±2.13)%,the differences were no significant.Group E(3.38±1.37)%compared with group A(7.85±2.13)%,group C (7.25±1.82)%,group D(8.63±3.18)%,the differences were significant,(P0.05).Conclusions The ratio of CD4+CD25+T cells to CD4+T cells of asthmatic rat exit predominance expression,which may be one of mechanisms of asthma pathogenesis.Dexamethasone can depress CD4+CD25+T cells predominance expression.The changes of CD4+CD25+T cells in BALF is consistent with that in the blood and spleen,which suggested that monitoring the changes of CD4+CD25+T cells in blood and spleen can be useful to understand the situatioan of BALF." @default.
- W2381567365 created "2016-06-24" @default.
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- W2381567365 date "2010-01-01" @default.
- W2381567365 modified "2023-09-23" @default.
- W2381567365 title "Change of CD4+CD25+ regulatory T cells in asthmatic rat and the effect of dexamethasone on CD4~+CD25~+T cells" @default.
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