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- W2381569262 abstract "Objective: To investigate the effect of Ghrelin on plasminogen activator inhibitor-1(PAI-1) mRNA expression in HepG2 cells induced by tumor necrosis factor-α(TNF-α) and the effect of nuclear factorκB(NF-κB).Methods:HepG2 cells were cultured.The mRNA expression of PAI-1 in HepG2 cells was detected by reverse transcription-polymerase chain reaction(RT-PCR).The protein expression was investigated by Western blot analysis.The concentration(0.1,1,10 μg·L-1) of TNF-α used to treat the HepG2 cells was selected.The effect of Ghrelin on PAI-1 mRNA expression in HepG2 cells induced by TNF-α was observed.Results:The mRNA expression of PAI-1 increased when HepG2 cells were exposed to different concentrations of TNF-α;the NF-κBp65 in nucleus increased slightly,IκBα in cytoplasm decreased.Ghrelin could markedly inhibit the increase of PAI-1 mRNA expression induced by TNF-α.The expression of IκBα in cytoplasm increased and the expression of NF-κBp65 in nucleus decreased with pretreatment of Ghrelin.Conclusion:The levels of PAI-1 mRNA expression in HepG2 cells increased after TNF-α exposure.Ghrelin could inhibit PAI-1 mRNA expression via NFκB." @default.
- W2381569262 created "2016-06-24" @default.
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- W2381569262 date "2008-01-01" @default.
- W2381569262 modified "2023-09-25" @default.
- W2381569262 title "Ghrelin inhibits PAI-1 mRNA expression in HepG2 cells induced by tumor necrosis factor-α via nuclear factor-κB" @default.
- W2381569262 hasPublicationYear "2008" @default.
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