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- W2381574185 abstract "AIM: Heterotopic transplantation of rat hypertrophic hearts has been shown to reverse chamber enlargement and regress cardiac myocyte hypertrophy.The purpose of this study was to gain a better understanding of molecular changes associated with the beneficial reverse remodeling after pressure unloading of hypertrophic heart.METHODS: Stable cardiac hypertrophy was induced by abdominal aortic constriction(AAC) in Lewis rats(6 weeks).Left ventricular(LV) pressure unloading was induced by heterotopic transplantation of hypertrophic hearts(AAC-HT) and/or normal hearts(NL-HT)(2 weeks).We measured heart weight(HW) and LV weight(LVW) of all groups.Cross-sectional area of cardiomyocyte was assessed by hematoxylin/eosin staining.We further analyzed the regulation of prohypertrophic signaling pathways of mitogen-activated protein kinases(MAPKs),Akt/GSK3β and NF-κB in both transplanted groups by Western blotting.RESULTS: The HW and LVW in AAC hearts were higher(P0.05) than those in normal controls,but the transplanted hearts in AAC-HT group showed a significant reduction in HW and LVW compared to the AAC hearts.Pressure unloading induced a decrease in cardiomyocyte size in AAC-HT and NL-HT hearts.A significant decrease in phosphorylation of p44/p42 MAP kinases(ERK),Akt,GSK3β and NF-κB was detected in AAC-HT hearts,but the phosphorylation of p38 MAP kinase and Jun-N-terminal kinase(JNK) were not changed compared to AAC hearts.The phosphorylation of MAPKs,Akt/GSK3β and NF-κB showed no difference between NL-HT hearts and normal controls.CONCLUSION: Pressure unloading of the hypertrophic heart caused a reverse remodeling through regulating the ERK,Akt/GSK3β,and NF-κB signal pathways which act as potential target pathways for reversal of LV hypertrophy." @default.
- W2381574185 created "2016-06-24" @default.
- W2381574185 creator A5045059006 @default.
- W2381574185 date "2009-01-01" @default.
- W2381574185 modified "2023-09-23" @default.
- W2381574185 title "Signal pathways involved in reverse remodeling of the hypertrophic heart in rat after pressure unloading" @default.
- W2381574185 hasPublicationYear "2009" @default.
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