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• W2381587946 abstract "Objective To study the association of apolipoprotein ( Apo) E gene polymorphism with difference in biochemical metabolism of diabetic nephropathy of Hui and Han populations. Methods ApoE genotype was determined by PCR-RFLP in diabetic patients with or without diabetic nephropathy (DN) and normal peoples in Hui and Han peoples, the related biochemical parameters were simultaneously detected. Results (1) Huis had 3 genotypes, i. e. E2/E3, E3/E3 and E3/E4, and their frequencies were 0. 043, 0. 894 and 0. 064, respectively. Hans had 5 genetypes, i. e. E2/E2, E2/E3 , E2/E4, E3/E3 and E3/E4, and their frequencies were 0.075,0.060, 0.164, 0.642 and 0.060, respectively. The frequencies of 3 alleles, E2, E3 and E4, in Huis and Hans were 0.021, 0.947, 0.032 and 0.187, 0. 702, 0.112, respectively. The results showed that difference in frequencies of genotypes and alleles of Huis and Hans was very significant (both P 0.01). (2) Type 2 diabetic patients without DN in Hans had 2 genotypes, E2/E4, E3/E3, and 3 alleles, E2, E3, E4, and their frequencies were 0.500, 0. 500 and 0. 250, 0. 500, 0. 250, respectively. Type 2 diabetic patients with DN in Hans had 4 genotypes E2/E2, E2/E3, E2/E4, E3/E3 and 3 alleles E2, E3, E4, and their frequencies were 0. 238,0.191, 0.191, 0. 381 and 0.429, 0.476, 0.095 respectively. The results showed that E2/E2 and E2/E3 genotypes were related to DN of type 2 diabetes. (3 ) In type 2 diabeitc patients with DN in Hans, the levels of serum triglyceride and total cholesterol in the patients with E2/E2 and E3/E3 were higher than those in the patients with E3/E3 and E2/E4; Urinary albumin excretion rate (UAER) , blood urea nitrogen (BUN) and blood creatinine (Cr) of the patients with E2/E2 were higher than those in patients with other genotypes (P 0. 05 or P 0. 01). However, only one genotype E3/E3 was detected in the patients of Huis. Conclusion Significant ethnic difference was found in Apo-E genotype and gene frequency between Hui and Han patients with DN. Biochemical parameters ( UAER, BUN, Cr) and levels of blood lipids also indicated the difference between Hui and Han patients with DN. The E2 allele and E2/E2 genotype could be related to blood lipids and biochemical abnomality in patients with DN in Han population, however, this relationship was not detected in DN Patient in Hui population. The result suggested that the susceptivity to DN was not related to E2 allele and E2/E2 genotype in DN patient in Hui population." @default.
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• W2381587946 title "Association of Apo-E gene polymorphism with biochemical and lipid metabolism parameters in patients with diabetic nephropathy of Hui and Han populations in Gansu Province" @default.
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