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- W2381592783 abstract "Objective: To observe the acute and long term toxicity of Total Clinopodium Glycosides (TCG) in mice and rats respectively. Method: The maximal tolerance dose was tested by gastric perfusion, the death circumstance of the animals in 7 days observed; Rats was divided into control group, three groups with high, moderate and low dosage of TCG (940,470,235 mg·kg -1 /d) with repeated gastric perfusion for 4 weeks and 2 weeks after drug withdrawal. Result: The maximal tolerance dose is 8.0 g·kg -1 /d, equal to 476.19 times of the dosage used in clinic for an adult. The test groups all can shorten blood clotting time obviously, the groups with high and moderate dosage goes up the blood TP and Alb level, showing obvious difference with control group, TCG high dosage group can lower the blood TC level obviously; the indexes of general condition, other blood routine testes , blood chemical analysis, organ coefficient of rats, pathological anatomic examination were not found obvious abnormality ;There was no significant difference between the test groups and the control in all tested parameters after drug withdrawal for 2 weeks. Conclusion: TCG has no obvious toxicity responds and postpones toxicity, which indicates TCG deserves safety." @default.
- W2381592783 created "2016-06-24" @default.
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- W2381592783 date "2005-01-01" @default.
- W2381592783 modified "2023-09-24" @default.
- W2381592783 title "Experimental Study on Toxicity of Total Clinopodium Glycosides Capsule" @default.
- W2381592783 hasPublicationYear "2005" @default.
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