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- W2381592922 abstract "Objective To investigate the effect of L-arginine(L-Arg)injection on asymmetric dimethylarginine(ADMA)and nitric oxide(NO)in patients with congenital heart disease complicated moderate or severe pulmonary artery hypertension(PAH)[pulmonary arterial systolic pressure(PASP)50 mm Hg].Methods Twenty patients undergoing surgical intervention under cardiopulmonary bypass(CPB)were randomized to two groups of Ⅰ(receiveing conventional treatment)and Ⅱ(giving additional L-Arg injection)with 10 patients each.Blood samples were taken before treatment,before anesthesia induction,at the end of CPB and 12,24 and 72 h after CPB for determinations of NO and ADMA concentrations.The PASP was recorded before treatment,before operation,on the first and the third postoperative day.Results There were no significant differences in ADMA,NO and PASP between two groups before treatment.In group Ⅰ,the NO was higher at T1 than T2,T4-T6,while ADMA was lower at T2-T6.In group Ⅱ,the NO was lower at T1 than T3-T6,but ADMA was higher at T4-T6(P0.05).The ADMA was lower and NO was higher in group Ⅰ compared with group Ⅱ at T2,T4-T6(P0.05).The PASP in group Ⅰ was lower than group Ⅱ at T2,T4,T6(P0.05).Conclusion CPB leads to an increase of ADMA and a decrease of NO,which may be reversed by L-Arg injection with a decrease of PAH in patients undergoing surgical intervention for congenital heart disease under CPB." @default.
- W2381592922 created "2016-06-24" @default.
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- W2381592922 date "2009-01-01" @default.
- W2381592922 modified "2023-09-28" @default.
- W2381592922 title "Effect of L-arginine injection on asymmetric dimethylarginine and nitric oxide in patients under cardiopulmonary bypass" @default.
- W2381592922 hasPublicationYear "2009" @default.
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