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- W2381595727 abstract "Objective To evaluate the influence of Xuebijing(XBJ) by inflammation cytokines of multiple organ dysfunction syndrome(MODS).Methods 90 rats were randomly separated into 3 groups,the control group and XBJ group were infused 15 μg/kg LPS in vena caudalis,Then the physical sign appearance was observed and collection the serum to determine the expression concentration of TNF-α、IL-1α、IL-4 and IL-10 by ELISA in each group at different times.Results ① The death rate of rats were the percent of 0,37,and 20 in the control group,model group and XBJ group,respectively.② The XBJ enhance the increased amplitude of TNF-α and deduce the increased amplitude of IL-1α by compared with model group,the expression concentration peak of TNF-α and IL-1α is 6~24 h.③ The expression concentration of IL-4 in model group and XBJ group in model group has significant ascendant compared with control group at 6~48 h;XBJ group has significant have significant ascendant compared with control group at 6~12 h(p0.05).The expression concentration of IL-10 ascendant compared with control group at 6h(p0.05).Conclusion The results demonstrated that XBJ could degrade the death rate of MODS induced by LPS,and it could reduce the increased amplitude of TNF-α,whereas enhance the increased amplitude of the serum IL-1α,IL-4 and IL-10,it could also prevent those rats from changing into MODS efficiently." @default.
- W2381595727 created "2016-06-24" @default.
- W2381595727 creator A5062959247 @default.
- W2381595727 date "2013-01-01" @default.
- W2381595727 modified "2023-09-24" @default.
- W2381595727 title "Study of the influence of xuebijing on inflammatory cytokine in multiple organ dysfunction syndrome in rat" @default.
- W2381595727 hasPublicationYear "2013" @default.
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