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- W2381600829 abstract "Objective: To observe dynamic changes of Angiopoietin-1(Ang-1) and the receptor tyrosine kinase that contains immunoglobulin-like loops and epidermal growth factor-similar domains-2(Tie-2) expression following intracerebral hemorrhage(ICH), which were known to be related with angiogenesis in basal ganglia of rat. Method: ICH rats were induced with Collagenase Ⅶ and the changes of brain were observed by HE staining and expression of Ang-1 and the receptor Tie-2 were assayed by immunohistochemistry on the 1st? 2nd?4th?7th?14th?21st and 28th d after the onset, then positive microvessels were counted. Result: No obvious pathology change appeared in brains of normal control and sham or sham group during the experiment, but for model group, microvessels appeared around hematoma on the 4th d, which got denser gradually and extended into hematoma on the 21st d. Immunohistochemistry revealed no change of expression of Ang-1 and Tie-2 in brains of normal control and sham or sham group during the experiment,and in ICH group, the expression of Ang-1 and Tie-2 were observed on the 2nd d,which increased gradually and peaked on the 21st d, then depressed on day 28. Conclusion: Expressions of Ang-1 and its receptor Tie-2 are up-regulated follwing ICH,which may play an important role in the course of microvascular networks reconstruction by promoting angiogenesis." @default.
- W2381600829 created "2016-06-24" @default.
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- W2381600829 date "2007-01-01" @default.
- W2381600829 modified "2023-09-22" @default.
- W2381600829 title "Dynamic changes of angiopoietin-1 and the receptor Tie-2 expression in rat brains following intracerebral hemorrhage" @default.
- W2381600829 hasPublicationYear "2007" @default.
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