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- W2381601402 abstract "Objective To investigate the effect of inhaled glucocorticosteroid treatment in airway remodeling in children with bronchial asthma(asthma).Methods Thirty hospitalized children(aged 5 to 15 years)with moderate-severe persistent asthma(asthma group),30 healthy children(control group),15 asthmatic cases regularly inhaled glucocorticosteroid for more than six months(remission group)were studied.Ultrasonically nebulized 5% hypertonic saline was used to induce sputum.The IL-5 level in induced sputum was determined using ELISA.Immunocytochemistry assay was used to determine TGF-β1 expression of inflammatory cells.The forced expiratory volume in first second percent(FEV1%)predicted(FEV1% pred)and the eosinophils(EOS)counting in the sputum were measured.The percentage of airway wall area to total airway cross sectional area(WA%)and wall thickness to airway diameter ratio(T/D)were calculated at the segmental and subsegmental on HRCT.Results ①The EOS counting and IL-5 level in induced sputum of astham group were(17.24±12.11)%,(25.45±18.05)pg/L,remission group were(3.66±2.13)%,(7.33±4.39)pg/L,control group were(1.4±1.27)%、(6.49±5.31)pg/L,there are statistical significant differences between asthma group and control group,and the remission group(P0.01).②Twenty-seven of 30 asthma cases showed positive expression of TGF-β1 in inflammatory cells in induced sputum,2 cases in the remission group,there is no positive expression of TGF-β1 in control group.③Asthma group T/D(18.16±2.42)%,WA%(59.25±6.54)%,FEV1% pred(71.82±23.08),remission group T/D(17.17±1.9)%,WA%(56.01±3.91)%,FEV1%pred(96.18±12.8)%.Control group T/D(16.45±2.30)%,WA%(53.91±7.72)%,FEV1%pred(107.46±17.11)%.Asthma and control group,and the remission group had a significant difference(P0.05).Conclusions Airway remodeling had formed in children with asthma.Inhaled glucocorticosteroid could regulate genesis and development of airway inflammation effectually.After a longer-term glucocorticosteroid inhalation reversed airway remodeling partly can be observed." @default.
- W2381601402 created "2016-06-24" @default.
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- W2381601402 date "2009-01-01" @default.
- W2381601402 modified "2023-09-28" @default.
- W2381601402 title "Effects of inhaled glucocorticosteroid treatment in airway remodeling in children with bronchial asthma" @default.
- W2381601402 hasPublicationYear "2009" @default.
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