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- W2381602958 abstract "Aim To evaluate whether Litsea Coreana level(TFLC) would have regulatory effects on the expressions of Leptin and TGF-β1 of hepatic fibrosis in rats.Methods The liver fibrosis model rats were in duced by injecting 50% CCl 4(1 ml.kg-1) twice a week for 12 weeks.From the first week,all the therapeutic groups were treated with TFLC(100,200,400 mg.kg-1) and the colchicines(0.1 mg.kg-1) respectively.At the end of the twelfth week,the levels of ALT,AST,HA,LN,P Ⅲ NP,CIV,Collagen Ι,Leptin,TGF-β1 in serum and Hyp in liver were measured.Masson staining was used to evaluate the degree of hepatic fibrosis.The mRNA and protein expressions of Ob-Rb,TGF-βR1 and Smad3 in liver were detected by RT-PCR and Western blot.Results TFLC(200 and 400 mg.kg-1) treatment significantly reduced the elevations of ALT,AST,HA,LN,PⅢNP,CIV,Collagen Ⅰ,Leptin,TGF-β1 in serum and Hyp in liver.In addition,TFLC treatment improved the morphologic changes of hepatic fibrosis,suppressed expressions of Ob-Rb,TGF-βR1,Smad3 in the liver fibrosis in rats.Conclusions TFLC is able to ameliorate liver injury and protect rats from liver fibrosis.This process may be related to inhibiting the expression of Ob-Rb,TGFβR1 and Smad3." @default.
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- W2381602958 date "2012-01-01" @default.
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- W2381602958 title "Regulatory effects of Litsea Coreana level on the expressions of Leptin and TGF-β1 to prevent the hepatic fibrosis in rats" @default.
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