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- W2381619697 abstract "OBJECTIVE: To establish the method for the determination of paliperidone (PA) concentration in the rat plasma, and to study pharmacokinetics of PA in rats. METHODS: 6 rats were given a single dose of 2.5 mg PA. The plasma concentration of PA was determined by RP-HPLC before medication and 0.25, 0.5, 1, 1.5, 2, 4, 8, 12, 24, 36, 48 h after medication, using risperidone as internal standard. Pharmaceutical parameters were calculated with DAS software. The analytic column was Scienhome Kromasil C18 with acetonitrile-0.1 mol/L Na2HPO4 (pH 6.0)(62 ∶ 38) at the flow rate of 1.0 ml/min. The detection wavelength was set at 237 nm and column temperature was 35 ℃. The injection volume was 20 μl. RESULTS: The linear range of PA were 0.01- 0.40 μg/ml (r=0.999 5). The method recoveries were 98.7%-102.2%, and extraction recoveries were 82.8%-85.8%. RSD of inter-day and intra-day were less than 9%. The plasma concentration-time curve of PA was fitted to two-compartment open pharmacokinetic model. The main pharmacokinetic parameters were as follows:cmax was (102.3±21.56) μg/L; tmax was (1.5±0.22) h; t1/2β was (14.969±5.651) h; Vd was(17.568±9.688) L; AUC0-48 h was (1 799.721±329.573) μg·h/L. CONCLUSIONS: This method is suitable for the determination of PA concentration in rat plasma. PA is eliminated slowly and then distributed widely in rats in vivo." @default.
- W2381619697 created "2016-06-24" @default.
- W2381619697 creator A5026600093 @default.
- W2381619697 date "2013-01-01" @default.
- W2381619697 modified "2023-09-26" @default.
- W2381619697 title "Plasma Concentration and Pharmacokinetic Study of Paliperidone in Rats by RP-HPLC" @default.
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