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- W2381622304 abstract "Objective: To observe effect of cerebral haemorrhage and panax notoginseng saponins(PNS) on subventricular zone(SVZ) cells of lateral ventricle in rat forebrain. Methods: Cerebral hemorrhage model were established by injecting with collagenase on caudate nucleus of adult male Wistar rats. The expression of proliferating cell nuclear antigen(PCNA), Tuj-1, glial fibrillary acidic protein(GFAP) and the expression and activation of basic ibroblast growth factor(BFGF) were determined by immunohistochemical method on SVZ cells of lateral ventricle after cerebral haemorrhage. To study the proliferation and differentiation of SVZ cells of lateral ventricle and the effect of PNS. Results: Through the immunohistochemical results of serial sections, the expression of PCNA, GFAP, Tuj-1 and bFGF positive cells increased in SVZ of lateral ventricle after cerebral haemorrhage. After the administration of PNS, the numbers of positive cells in the treatment group increased significantly, there were significant differences compared with model group(P0.05, P0.01). Conclusion: Cerebral hemorrhage could activate neural stem cells in SVZ of lateral ventricle in rats forebrain and promote proliferation and differentiation. PNS could promote the above effects through enhancing the forebrain BFGF expression." @default.
- W2381622304 created "2016-06-24" @default.
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- W2381622304 date "2014-01-01" @default.
- W2381622304 modified "2023-09-26" @default.
- W2381622304 title "Effect of cerebral haemorrhage and panax notoginseng saponins on subventricular zone cells of lateral ventricle in rat forebrain" @default.
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