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- W2381630018 abstract "Objective To investigate whether PCF could inhibit apoptosis of HaCaT cells induced by ultraviolet B and to examine the effect of PCF on the ERKs/mitogen-activated protein kinases(ERKs/MAPKs) cascade and Caspase-3 in vitro.(Methods Cellular) experiments were designed into 6 groups(control,model,UVB+5.69 mmol /L PCF,UVB+2.84 mmol/L PCF,UVB+1.42 mmol/L PCF and UVB+5.69 mmol/L Vit C).Gel electrophoresis was used to observe the DNA ladder of each group with or without Caspase-3 inhibitor,ERKs pathways inhibitor;and Western blot was used to detect the activity of p-ERKs,P-MEKs,ERKs,and MEKs. Results PCF inhibited UVB-induced DNA ladder in HaCaT cells;ERKs pathways inhibitor increased the fragment of DNA by UVB;but the inhibition of Caspase-3 reduced the fragment of DNA;PCF enhanced the activity of P-ERKs and P-MEKs,but did not affect the activity of ERKs or MEKs. Conclusion PCF has protective effects against UVB-induced apoptotic cell death in HaCaT cells and PCF is likely to exert its cytoprotective effect in HaCaT cells through ERKs/MAPKs activation and caspase cascade." @default.
- W2381630018 created "2016-06-24" @default.
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- W2381630018 date "2006-01-01" @default.
- W2381630018 modified "2023-09-26" @default.
- W2381630018 title "EFFECTS OF POLYPEPTIDE FROM CHLAMYS FARRERI ON UVB-INDUCED HaCaT CELL APOPTOSIS AND MODULATES ERKS SIGNALING PATHWAYS" @default.
- W2381630018 hasPublicationYear "2006" @default.
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