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- W2381633829 abstract "Background: Interleukin (IL)-18 is a proinflammatory cytokine and plays important regulating roles in various immune reactions. Aims: To observe the effects of IL-18 on the production of T helper type 1 (Th1) cytokines, such as interferon (IFN)-γ and IL-2, and the activation of nuclear factor (NF)-κB in the mononuclear cells, and to unravel the regulating role of IL-18 on the mononuclear cells and its mechanism. Methods: The murine splenic mononuclear cells (SMC) were previously stimulated by different doses of IL-18 or IL-18+IL-12, then the expression of IFN-γ mRNA and IL-2 ■ were examined by reverse transcriptase polymerase chain reaction (RT-PCR), and the production of their proteins were measured by enzyme-linked immunosorbent assay (ELISA). The activation of NF-κB was tested by electrophoretic mobility shift assay (EMSA). Results: After stimulated with IL-18, the production of IFN-γ protein in SMC supernatant increased according to the increasing concentrations of IL-18. While co-stimulated with 100 ng/ml IL-18 and different concentrations of IL-12, the production of IFN-γ protein increased according to the increasing concentrations of IL-12, significant difference could be found between the stimulated groups and the controls (P0.05). The production of IL-2 protein did not change markedly in all stimulated groups when compared with the controls (P0.05). After stimulated with IL-18 or IL-18+IL-12, NF-κB was activated in SMC. Conclusions: The secretion of Th1 cytokine, IFN-γ, can be induced by IL-18 with or without IL-12 in mononuclear cells. NF-κB activation is involved in the signaling pathway of this process." @default.
- W2381633829 created "2016-06-24" @default.
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- W2381633829 date "2004-01-01" @default.
- W2381633829 modified "2023-09-23" @default.
- W2381633829 title "The Regulating Role of Interleukin-18 on Mononuclear Cells and its Mechanism" @default.
- W2381633829 hasPublicationYear "2004" @default.
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